Antihyperlipidemic effect of crude extract of saffron stigma (Crocus sativus) in healthy male rats

Iliass Lahmass; Sabir Ouahhoud; Assia Sabouni; Mohammed Elyoubi; Redouane Benabbas; Rachid Elmoussaoui; Mohammed Choukri; Ennouamane Saalaoui

doi:10.5455/jmas.248536

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Original Article
Online Published: 27 Dec 2016

J Med Allied Sci. 2017; 7(1): 20-25

doi: 10.5455/jmas.248536

Antihyperlipidemic effect of crude extract of saffron stigma (Crocus sativus) in healthy male rats

Iliass Lahmass, Sabir Ouahhoud, Assia Sabouni, Mohammed Elyoubi, Redouane Benabbas, Rachid Elmoussaoui, Mohammed Choukri, Ennouamane Saalaoui.

Cited By: 1

Abstract
In this study, we investigated for the first time the antihyperlipidemic ef-fects of crude extract of stigmas from Crocus sativus (saffron) against hyperlipidemia induced by tartrazine (synthetic dye) in normal male rats. Thirty adult male albino rats weighing about 150 - 200 g, were divided into 5 groups (n = 6) and daily treatment was given orally. Clinical biochemis-try and metabolic parameters were evaluated at the end of the experiment and after 105 days. (n=6, for all groups). Our data revealed that the meta-bolic parameters like consumption of food and water, pH and urine vol-ume have not been affected; also the difference between liver, right kid-ney and heart weight was not significant. The levels of cholesterol and triglyceride were significantly increased in group 2 and group 3 compared to control group. There was no significant difference in the level of cholesterol and triglyceride in group 4. Treatment with saffron alone did not have any significant effects on the level of fat compared to control group. The oral administration of the crude extract of saffron revealed good hypolipidemic effects in adult male albino rats. These results suggest that aqueous saffron extract reduced plasma cholesterol and decreased triglyceride. Therefore, it could conceivably lead to suitable changes in blood lipid profiles.

Key words: Antihyperlipidemic effect, Crocus sativus, Saffron, Tartrazine

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Pubmed Style

Lahmass I, Ouahhoud S, Sabouni A, Elyoubi M, Benabbas R, Elmoussaoui R, Choukri M, Saalaoui E. Antihyperlipidemic effect of crude extract of saffron stigma (Crocus sativus) in healthy male rats. J Med Allied Sci. 2017; 7(1): 20-25. doi:10.5455/jmas.248536

Web Style

Lahmass I, Ouahhoud S, Sabouni A, Elyoubi M, Benabbas R, Elmoussaoui R, Choukri M, Saalaoui E. Antihyperlipidemic effect of crude extract of saffron stigma (Crocus sativus) in healthy male rats. https://jmas.in/?mno=248536 [Access: June 27, 2026]. doi:10.5455/jmas.248536

AMA (American Medical Association) Style

Lahmass I, Ouahhoud S, Sabouni A, Elyoubi M, Benabbas R, Elmoussaoui R, Choukri M, Saalaoui E. Antihyperlipidemic effect of crude extract of saffron stigma (Crocus sativus) in healthy male rats. J Med Allied Sci. 2017; 7(1): 20-25. doi:10.5455/jmas.248536

Vancouver/ICMJE Style

Lahmass I, Ouahhoud S, Sabouni A, Elyoubi M, Benabbas R, Elmoussaoui R, Choukri M, Saalaoui E. Antihyperlipidemic effect of crude extract of saffron stigma (Crocus sativus) in healthy male rats. J Med Allied Sci. (2017), [cited June 27, 2026]; 7(1): 20-25. doi:10.5455/jmas.248536

Harvard Style

Lahmass, I., Ouahhoud, . S., Sabouni, . A., Elyoubi, . M., Benabbas, . R., Elmoussaoui, . R., Choukri, . M. & Saalaoui, . E. (2017) Antihyperlipidemic effect of crude extract of saffron stigma (Crocus sativus) in healthy male rats. J Med Allied Sci, 7 (1), 20-25. doi:10.5455/jmas.248536

Turabian Style

Lahmass, Iliass, Sabir Ouahhoud, Assia Sabouni, Mohammed Elyoubi, Redouane Benabbas, Rachid Elmoussaoui, Mohammed Choukri, and Ennouamane Saalaoui. 2017. Antihyperlipidemic effect of crude extract of saffron stigma (Crocus sativus) in healthy male rats. Journal of Medical and Allied Sciences, 7 (1), 20-25. doi:10.5455/jmas.248536

Chicago Style

Lahmass, Iliass, Sabir Ouahhoud, Assia Sabouni, Mohammed Elyoubi, Redouane Benabbas, Rachid Elmoussaoui, Mohammed Choukri, and Ennouamane Saalaoui. "Antihyperlipidemic effect of crude extract of saffron stigma (Crocus sativus) in healthy male rats." Journal of Medical and Allied Sciences 7 (2017), 20-25. doi:10.5455/jmas.248536

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Lahmass, I., Ouahhoud, . S., Sabouni, . A., Elyoubi, . M., Benabbas, . R., Elmoussaoui, . R., Choukri, . M. & Saalaoui, . E. (2017) Antihyperlipidemic effect of crude extract of saffron stigma (Crocus sativus) in healthy male rats. Journal of Medical and Allied Sciences, 7 (1), 20-25. doi:10.5455/jmas.248536

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