E-ISSN 2231-170X | ISSN 2231-1696
 

Original Article 


Analysis of BCL-2 protein expression in keratinocytic hyperproliferative lesions

Abhishek Agrawal, K. Indrani, A. N. Roopa, S. R. Raja Parthiban.

Abstract
Apoptosis regulates keratinocytic proliferation and formation of stra-tum corneum in skin and is regulated by proteins like BCL-2 which con-trols cell survival and p53 which regulates cell death. Dysfunctional apoptosis plays an important role in development of hyperproliferative skin disorders including non-tumorigenic, pre-tumorigenic and tumor-igenic conditions. Therefore, we conducted a study to analyze the ex-pression pattern of apoptosis regulating protein BCL-2 in keratinocytic hyperproliferative lesions. The aim of this study was to evaluate and compare BCL-2 expression in various non-tumorigenic, pre-tumorigenic and tumorigenic keratinocytic hyperproliferative lesions. Skin biopsies of hyperproliferative keratinocytic lesions were studied from October 2018 to September 2020. The cases were categorized into 3 groups based on histological diagnosis (non-tumorigenic, pre-tumorigenic and tumorigenic). Following this, IHC for BCL-2 was performed on all cases using standard protocol. Tumorigenic lesions included 7 cases of SCC, pre-tumorigenic included 6 cases of seboherric keratosis, 2 cas-es of condyloma acuminata, 1 case of epidermodysplasia verruciform-is and 1 case of actinic keratosis, while the remaining 35 cases were non-tumorigenic, including psoriasis (6 cases), verruca vulgaris (4 cas-es), lichen planus (12 cases), chronic dermatitis (9 cases) and lichen simplex chronicus (4 cases). BCL-2 average weighted score in non-tumorigenic lesions was (1.25±1.13) as compared with pre-tumorigenic and tumorigenic lesions (5.30±3.32) and thus showing a significant p value (p<0.001). To conclude, significantly increased BCL-2 expression in neoplastic lesions shows that increased cell survival may contribute to neoplastic transformation.

Key words: Apoptosis, BCL-2, Non-tumorigenic, Pre-tumorigenic, Tumorigenic


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Abhishek Agrawal
Articles by K. Indrani
Articles by A. N. Roopa
Articles by S. R. Raja Parthiban
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Agrawal A, Indrani K, Roopa AN, Parthiban SRR. Analysis of BCL-2 protein expression in keratinocytic hyperproliferative lesions. J Med Allied Sci. 2021; 11(2): 114-119. doi:10.5455/jmas.10363


Web Style

Agrawal A, Indrani K, Roopa AN, Parthiban SRR. Analysis of BCL-2 protein expression in keratinocytic hyperproliferative lesions. https://jmas.in/?mno=10363 [Access: December 05, 2023]. doi:10.5455/jmas.10363


AMA (American Medical Association) Style

Agrawal A, Indrani K, Roopa AN, Parthiban SRR. Analysis of BCL-2 protein expression in keratinocytic hyperproliferative lesions. J Med Allied Sci. 2021; 11(2): 114-119. doi:10.5455/jmas.10363



Vancouver/ICMJE Style

Agrawal A, Indrani K, Roopa AN, Parthiban SRR. Analysis of BCL-2 protein expression in keratinocytic hyperproliferative lesions. J Med Allied Sci. (2021), [cited December 05, 2023]; 11(2): 114-119. doi:10.5455/jmas.10363



Harvard Style

Agrawal, A., Indrani, . K., Roopa, . A. N. & Parthiban, . S. R. R. (2021) Analysis of BCL-2 protein expression in keratinocytic hyperproliferative lesions. J Med Allied Sci, 11 (2), 114-119. doi:10.5455/jmas.10363



Turabian Style

Agrawal, Abhishek, K. Indrani, A. N. Roopa, and S. R. Raja Parthiban. 2021. Analysis of BCL-2 protein expression in keratinocytic hyperproliferative lesions. Journal of Medical and Allied Sciences, 11 (2), 114-119. doi:10.5455/jmas.10363



Chicago Style

Agrawal, Abhishek, K. Indrani, A. N. Roopa, and S. R. Raja Parthiban. "Analysis of BCL-2 protein expression in keratinocytic hyperproliferative lesions." Journal of Medical and Allied Sciences 11 (2021), 114-119. doi:10.5455/jmas.10363



MLA (The Modern Language Association) Style

Agrawal, Abhishek, K. Indrani, A. N. Roopa, and S. R. Raja Parthiban. "Analysis of BCL-2 protein expression in keratinocytic hyperproliferative lesions." Journal of Medical and Allied Sciences 11.2 (2021), 114-119. Print. doi:10.5455/jmas.10363



APA (American Psychological Association) Style

Agrawal, A., Indrani, . K., Roopa, . A. N. & Parthiban, . S. R. R. (2021) Analysis of BCL-2 protein expression in keratinocytic hyperproliferative lesions. Journal of Medical and Allied Sciences, 11 (2), 114-119. doi:10.5455/jmas.10363