Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis

Nazima Begum; Syed Mohammed Akbar Hassan; Purushottam Padmanabhan; Shaik Iqbal Ahmed; Avinash Bardia; Aleem Ahmed Khan

doi:10.5455/jmas.49688

2025, Vol: 15, Issue: 2

15 / 2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Review Article
Online Published: 29 Sep 2022

J Med Allied Sci. 2021; 11(2): 105-113

doi: 10.5455/jmas.49688

Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis

Nazima Begum, Syed Mohammed Akbar Hassan, Purushottam Padmanabhan, Shaik Iqbal Ahmed, Avinash Bardia, Aleem Ahmed Khan.

Cited By: 1

Abstract
It has been estimated that 4.4 billion individuals are infected with Helicobacter pylori and the prevalence of the infection varies globally ranging from the highest reported in Africa (70.1%) to lowest in Switzerland (18.9%). The prevalence is still abundant in developing countries and is due to the outcome of low socioeconomic status and poor sanitation. Helicobacter pylori infection is implicated in several pathological states and is confronting a gigantic challenge to the global health community. This review provides an extensive picture of Helicobacter pylori infection prevalence and its association with disease outcomes using myriad sample studies, emphasizing detection using gastric biopsy. Moreover novel molecular mechanisms unveiled to date are also presented to better comprehend the underlying events that triggers the epidemiological effects. Data and mechanistic pathways presented in this review aid in improved regulation of Helicobacter pylori infection and assists in designing and crafting new drugs to treat the associated clinical conditions.

Key words: miRNA, Cancer, H.pylori, CagA

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How to Cite this Article

Pubmed Style

Begum N, Hassan SMA, Padmanabhan P, Ahmed SI, Bardia A, Khan AA. Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. J Med Allied Sci. 2021; 11(2): 105-113. doi:10.5455/jmas.49688

Web Style

Begum N, Hassan SMA, Padmanabhan P, Ahmed SI, Bardia A, Khan AA. Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. https://jmas.in/?mno=49688 [Access: June 22, 2026]. doi:10.5455/jmas.49688

AMA (American Medical Association) Style

Begum N, Hassan SMA, Padmanabhan P, Ahmed SI, Bardia A, Khan AA. Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. J Med Allied Sci. 2021; 11(2): 105-113. doi:10.5455/jmas.49688

Vancouver/ICMJE Style

Begum N, Hassan SMA, Padmanabhan P, Ahmed SI, Bardia A, Khan AA. Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. J Med Allied Sci. (2021), [cited June 22, 2026]; 11(2): 105-113. doi:10.5455/jmas.49688

Harvard Style

Begum, N., Hassan, . S. M. A., Padmanabhan, . P., Ahmed, . S. I., Bardia, . A. & Khan, . A. A. (2021) Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. J Med Allied Sci, 11 (2), 105-113. doi:10.5455/jmas.49688

Turabian Style

Begum, Nazima, Syed Mohammed Akbar Hassan, Purushottam Padmanabhan, Shaik Iqbal Ahmed, Avinash Bardia, and Aleem Ahmed Khan. 2021. Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. Journal of Medical and Allied Sciences, 11 (2), 105-113. doi:10.5455/jmas.49688

Chicago Style

Begum, Nazima, Syed Mohammed Akbar Hassan, Purushottam Padmanabhan, Shaik Iqbal Ahmed, Avinash Bardia, and Aleem Ahmed Khan. "Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis." Journal of Medical and Allied Sciences 11 (2021), 105-113. doi:10.5455/jmas.49688

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Begum, N., Hassan, . S. M. A., Padmanabhan, . P., Ahmed, . S. I., Bardia, . A. & Khan, . A. A. (2021) Prevalence and comprehensive insights into molecular mechanisms in Helicobacter pylori pathogenesis. Journal of Medical and Allied Sciences, 11 (2), 105-113. doi:10.5455/jmas.49688

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